The new NICE guideline advises that Exenetide Prolonged Release can be used instead of normal Exenetide and is given just once weekly rather than twice daily. It causes fewer side-effects (on the GI / hypo front). It is more cost-effective than normal Exenetide. Allthough it is a little more expensive, it gives a better drop in HbA1c.
The indications for it’s use are the same as for normal exenetide.