Nice | Familial breast cancer

7th March 2014 by NASGP

Each year in the UK 49,000 women and 400 men are diagnosed with breast cancer. Only 20% of patients have a positive family history, with 5% of breast cancers being attributable to specific mutations in BRCA1, BRAA2 and TP53 genes.

In recent years several high profile celebrities have helped raised awareness of familial breast cancer. In fact, Angelina Jolie timed her bilateral mastectomy perfectly with publication of the new NICE guidelines on the topic in June 2013! Personally, I find this guidance useful in identifying those who need referral from the ‘worried well’ and the public information leaflet helpful in counselling the latter on reducing their risk.

Definitions

Before we focus at what the guidelines say, let’s look at the definitions we need when taking a family history.

Family history definitions

  • First-degree relatives: mother, father, brother, sister, son, daughterSecond-degree relatives: grandparents, aunt, uncle, nephew, niece, grandchild, half-sibling
  • Third-degree relatives: great-grandparent, great aunt/uncle, first cousin, great-grandchild, great-niece/nephew

Join

Join to view the rest of this content, as well as access all the benefits of joining NASGP.

Join

Login

Already a member? Login to view this content.

Login

"Work as GP locum provides me both flexibility and autonomy together with great job satisfaction. However, there are some complexities one needs to address in starting out and doing everything right.

I've generally found answers to any issues I've had on the NASGP website – an excellent repository of very relevant information. The blog and magazines alone are almost worth the small costs of membership. The fact that NASGP is run by motivated fellow GPs gives me confidence in their guidance and advice.

LocumDeck makes my running things as a self-employed GP almost effortless - I don't think I would want to work without it. Invoicing is streamlined and the website is very user-friendly. After a busy week at work, the last thing you want is to spend hours on business admin. LocumDeck is a real timesaver.
"

Dr James O’Mahony

See the full list of features within our NASGP membership plans

Membership