Gestational trophoblastic disease – a new RCOG guideline

29th March 2021 by Dr Louise Hudman

Gestational trophoblastic disease – a new RCOG guideline

This is a new guideline from RCOG, published in June 2020, on managing Gestational Trophoblastic Disease (GTD).

Most of the management of GTD will not be done by us and will normally be done by one of three tertiary centres. However, I thought this guideline worth blogging on as there is a useful section on when to suspect it and this is highly relevant to us. I will just summarise the bits I felt were useful for GPs.

Can’t remember anything about GTD? GTD covers a range of conditions. Here’s a quick reminder…

  • It includes two pre-malignant conditions. These are complete and partial molar pregnancies (hydatidiform moles). In a complete molar pregnancy, all the genetic material comes from the father (normally when two sperm enter an empty ovum). There is no fetal tissue present. In a partial molar pregnancy, there is genetic material from the mother and father. This happens when two sperm enter an ovum. There is normally fetal tissue present.
  • It also includes four malignant conditions (known as Gestational trophoblastic neoplasia or GTN). These include invasive molar pregnancies and choriocarcinoma.

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