Dapagliflozin in heart failure

19th April 2021 by Dr Louise Hudman

Dapagliflozin in heart failure

This is a new guideline from NICE, published in February, advising that dapagliflozin can now be used in heart failure.

Isn’t dapagliflozin for diabetes?

Yes it is. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It reduces glucose reabsorption in the kidneys.

As it does this, it also reduces sodium reabsorption. This increased excretion leads to an osmotic diuresis.

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