Dapagliflozin in chronic kidney disease (CKD)

This is new guidance from NICE advising that dapagliflozin can be used for certain patients with CKD. This was released in March 2022.

When can dapagliflozin be used to treat chronic kidney disease (CKD)?

It can be used for treating CKD in adults. It can be used for the following patients.

• Patients should be on optimised doses of ACE inhibitor (ACEi) or Angiotensin II receptor blockers (A2RBs) (unless contraindicated) before adding on dapagliflozin AND
  • Have an eGFR of 25 to 75 at the start of treatment AND
    • Have T2DM with any albumin-to-creatinine ratio (ACR) OR
      • Have ACR of 22.6 mg/mmol or more if they don’t have type 2 diabetes mellitus (T2DM).

Can GPs prescribe dapagliflozin for patients without diabetes?

Yes, patients without T2DM can, as long as their ACR is above 22.6.