This is an update of the last Nice guideline on type 2 diabetes in adults, which was published in 2009. I am just summarising things that have changed since the last update. If you don't want to read anything else, just be aware that Nice has produced an excellent single A4 summary of what drugs to use when.
Nice advise that these targets can be tailored to the patient. They also advise that the targets can be relaxed if the side-effects from medications, or if the effort to reach that target impairs their quality of life.
- 48 mmol/mol (6.5%) = target for people just managed with lifestyle or on a single drug which doesn't cause hypoglycaemia.
- 53 mm0l/mol (7%) = target for people on drugs which cause hypoglycaemia.
- 58 mmol/mol (7.5%) or above:
- Offer encouragement
- Lifestyle advice
- Intensify drug treatment
This is largely the same and the differences are subtle. Nice no longer advising doing BMs routinely twice a week. They also no longer advise monitoring with illness, though they do acknowledge that you need to be aware of the risk of hyperglycaemia with illness. Previously they advised monitoring if on oral medication that could cause hypos, but now they only advise testing if they are also driving or operating machinery.
They also advise monitoring if the patient is on steroids, or if you need to confirm that hypos are happening.
As mentioned above, there is an excellent A4 sheet produced by NICE that I have saved to my Google Drive for easy reference.
Double therapy needed
The biggest difference to the 2009 guidance is that after metformin, you can add on either a sulphonylurea, pioglitazone, a DDP-4i or (if indicated) an SGLT-2.
NB - DDP-4i drugs are the gliptins and the SGLT-2 are the gliflozins.
Triple therapy needed
If you need to add on a third drug, you can choose from:
- DDP-4i + sulphonylurea
- Pioglitazone+ sulphonylurea
- Pioglitazone OR sulphonylurea + SGLT-2 (only canagliflozin or empagliflozin at present, though dapagliflozin may get approval soon for triple therapy).
e.g. exenetide = Byetta and liraglutide = Victoza
Can be used alongside metformin and a sulphonylurea if triple therapy is not effective, not suitable or not tolerated and if:
- BMI > 35 AND specific psychological or health problems associated with obesity OR
- BMI < 35 AND insulin would have occupational consequences OR weight loss would benefit other obesity related conditions.
Useful notes on drugs (not all of this is new, but I'd forgotten it...):
- Metformin - they are not specifying a creatinine level to be careful about now, just a GFR level (ie review use if GFR < 45 and stop if GFR < 30).
- Pioglitazone - there are lots of contraindications. Review use after 3-6m and only continue it if the patient is getting benefit.
- Gliflozins - can cause ketoacidosis even with a normal BM and can continue to do this even for a 'short while' after stopping them. If you want a reminder of these drugs and what their indications are, there are links to my blogs on them below:
Nice have lowered the target a little for those with no other complications. It is now 140/80. They do specify that it is OK to trial lifestyle treatment first to get the blood pressure down.
Do not use aspirin for primary prevention.
Lipid Lowering Treatment
There is nothing new in this guideline. NICE produced previous advice which covers type 2 diabetics. Basically for primary prevention, use QRISK-2 and if the risk is 10% or more, start atorvastatin 20mg.
Again there is nothing new here. NICE produced previous guidance which covers type 2 diabetics. The main difference is that an ACR ≥ 3 is felt to be abnormal in both men and women.
Again, nothing new here. NICE produced previous guidance which covers type 2 diabetics. Basically you can use any of a TCA, duloxetine, gabapentin or pregabalin as first line, then try any of the others if needed.
Diabetic foot problems
See my blog covering this, which was released in a separate recent Nice guideline.