Nice | Naloxegol to treat opioid induced constipation

This is a new guideline from Nice advising that naloxegol can be used for treating opioid induced constipation. Naloxegol is a form of naloxol which has been pegalated and selectively antagonises peripheral opioid receptors. It can be used IF

  • the constipation has not responded adequately to at least one other class of laxative taken for at least 4 days in the previous 2 weeks


  • symptoms are of at least moderate severity and include at least 1 of:
    • incomplete bowel movement.
    • hard stools.
    • straining.
    • false alarms.

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