This is a new guideline from Nice advising that naloxegol can be used for treating opioid induced constipation. Naloxegol is a form of naloxol which has been pegalated and selectively antagonises peripheral opioid receptors. It can be used IF
- the constipation has not responded adequately to at least one other class of laxative taken for at least 4 days in the previous 2 weeks
- symptomsÂ are of at least moderate severity and include at least 1 of:
- incomplete bowel movement.
- hard stools.
- false alarms.