Nice | Lubiprostone for treating chronic idiopathic constipation

This is guideline from NICE on a newly recommended treatment for chronic idiopathic constipation.

The medication is Lubiprostone, which works by activating chloride channels in the GI tract, thus increasing intestinal secretions and improving constipation.

It has a different method of action to prucalopride, which NICE released guidance on in 2011. Lubiprostone is more cost-effective than prucalopride.

We can use Lubiprostone in adults who have chronic idiopathic constipation and who meet the following criteria:

  • Have tried at least 2 different laxatives from different classes
  • For at least 6m
  • Have failed to have an adequate response
  • Where lifestyle measures have not been effective
  • In whom invasive treatment is being considered

It should work within 2 weeks, so patients should be reviewed then and it should be stopped if it has not worked.

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