Nice | Idelalisib for treating chronic lymphocytic leukaemia

This is a new guideline from NICE on idelalisib use in chronic lymphocytic leukaemia. Idelalisib is likely to be secondary care prescribed, but I felt it was worthwhile knowing about as it is a new type of drug and we will probably see patients on it.

Idelalisib is an oral drug and will be used in combination with rituximab infusions. It is a 'first-in-class' drug which inhibits enzymes involved in cell proliferation, death and migration.


Among other side-effects, it can raise transaminases, triglycerides and can cause neutropenia.

[Tweet "Idelalisib; watch out for raised transaminases, triglycerides and neutropenia."]

I’m a freelance GP locum in Winchester & Southampton.

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